Lung Tx


French Biopsy series of 100 patients KI Reports 2024

  • Main Biopsy Indication: Chronic renal dysfunction in 72% of patients.
  • Timing: Biopsies occurred at a median of 26.3 months post-transplantation and 15 months after signs of renal impairment.
  • Frequent Findings: Arteriosclerosis, acute calcineurin inhibitor toxicity, thrombotic microangiopathy (TMA), and acute tubular necrosis.
  • TMA Correlation: Strongly associated with combined mTOR inhibitors and calcineurin inhibitors.
  • ESRD Risk Factors: Postoperative dialysis, proteinuria >3 g/g, and glomerulosclerosis >4%.
  • ESRD Outcome: 34 patients progressed to ESRD approximately 20.1 months after biopsy​