IV has lower bladder toxicity vs oral
Immediate (e.g., gastrointestinal, susceptibility to infection)
The risk of future hematologic malignancy is related to total lifetime exposure (>36 g), as is myelofibrosis (>80 g).
Total lifetime exposure plus age constitutes a significant risk factor for premature ovarian failure (>7.5–15 g/m2 for young to older pediatric patients, respectively; 300 mg/kg for adults).